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SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS › PANCREATIC HORMONES › GLYCOGENOLYTIC HORMONES › Glycogenolytic hormones
dasiglucagon
H04AA02
Forms & Strengths
- 0.5mg/mL pre-filled syringe
- 0.5mg/mL pre-filled auto-injector
Adult Dosing
- 0.6mg for severe hypoglycemia
- Administered via subcutaneous injection
Pediatric Dosing
- 0.6mg for children 6 years and older for severe hypoglycemia
- 0.6mg for children under 6 years, given by a caregiver
Indications
- Treatment of severe hypoglycemia in diabetes patients
- Diagnosis of suspected insulinoma
Mechanism of Action
- Glucagon receptor agonist
- Increases blood glucose through glycogenolysis and gluconeogenesis
Contraindications
- Pheochromocytoma
- Insulinoma
- Known hypersensitivity to dasiglucagon or any component
Adverse Reactions
- Nausea
- Vomiting
- Headache
- Injection site reactions
- Hypersensitivity reactions
Drug Interactions
- Beta-blockers may blunt the increase in heart rate and blood pressure
- Indomethacin may increase the hypoglycemic effect of dasiglucagon
- Warfarin may interact with dasiglucagon
Curated Content: Needs Vetting Before Put to Clinical Use