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SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS › CALCIUM HOMEOSTASIS › ANTI-PARATHYROID AGENTS › Calcitonin preparations
calcitonin (pork natural)
H05BA02
Forms & Strengths
- Injectable solution: 1 mL single-dose vials or ampules (2000 units/mL Miacalcin)
- Nasal spray: 1.7 mL (2000 units/mL) Miacalcin
- Injectable: 2000 units/mL Fortical
Adult Dosing
- Paget disease: 100 units SC/IM daily
- Hypercalcemia: 4 units/kg SC/IM every 12 hours
- Osteoporosis: 100 units SC/IM every other day or 200 units intranasally daily
Pediatric Dosing
- Not established for Paget disease and osteoporosis
- Hypercalcemia: 4-8 units/kg SC/IM every 6-12 hours
Indications
- Moderate to severe Paget disease of bone
- Hypercalcemia
- Postmenopausal osteoporosis
Mechanism of Action
- Regulates calcium and phosphorus metabolism by inhibiting osteoclast activity
- Increases renal excretion of calcium, phosphate, and sodium
Contraindications
- Hypersensitivity to calcitonin or any component of the formulation
- Low calcium levels
Adverse Reactions
- Nausea and vomiting (common with IV administration)
- Flushing and rash
- Local reactions at injection site
- Nasal irritation with intranasal spray
- Hypocalcemia
Drug Interactions
- Hydrocortisone and glucocorticoids: increased effects of calcitonin
- Thiazides and loop diuretics: decreased effect of calcitonin
- Cholestyramine and phenytoin: reduced absorption with calcitonin nasal spray
Curated Content: Needs Vetting Before Put to Clinical Use