← Search & browse all drugs
SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS › CALCIUM HOMEOSTASIS › ANTI-PARATHYROID AGENTS › Calcitonin preparations
calcitonin (human synthetic)
H05BA03
Forms & Strengths
- Injectable solution: 0.5 mg/vial
Adult Dosing
- Paget's disease: 0.5 mg subcutaneously daily, may decrease to 0.25 mg daily or alternate days
- Hypercalcemia: 0.25 mg to 0.5 mg subcutaneously or intramuscularly every 6 to 12 hours
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established
Indications
- Symptomatic Paget's disease of bone
- Emergency treatment of hypercalcemia
Mechanism of Action
- Binds to osteoclast receptors, inhibiting bone resorption and reducing serum calcium
Contraindications
- Hypersensitivity to synthetic human calcitonin or its excipients
- History of severe allergic reaction to calcitonin products
Adverse Reactions
- Nausea with or without vomiting
- Local inflammatory reactions at the injection site
- Flushing of the face or hands
- Increased urinary frequency
- Chills and dizziness
Drug Interactions
- Concurrent use with lithium may lead to a reduction in plasma lithium concentrations
- Potential additive hypocalcemic effects with other agents that lower serum calcium
Curated Content: Needs Vetting Before Put to Clinical Use