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SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS › CALCIUM HOMEOSTASIS › ANTI-PARATHYROID AGENTS › Other anti-parathyroid agents
doxercalciferol
H05BX03
Forms & Strengths
- Capsule: 0.5mcg
- Injection: 2mcg/mL
- Oral solution: 2mcg/mL
Adult Dosing
- Initially 10mcg PO three times a week for CKD patients
- Initially 4mcg IV or 10mcg PO three times a week for dialysis patients
Pediatric Dosing
- Limited data available for pediatric patients
- Dose must be individualized based on clinical and biochemical data
Indications
- Treatment and prevention of secondary hyperparathyroidism in CKD
- Treatment of metabolic bone disease in patients with osteoporosis
Mechanism of Action
- Prohormone of calcitriol, undergoes activation in liver
- Increases absorption of calcium from GI tract and mobilizes calcium from bone
Contraindications
- Known hypersensitivity to doxercalciferol
- Hypercalcemia or excessive vitamin D
- Vitamin D toxicity
Adverse Reactions
- Hypercalcemia
- Hyperphosphatemia
- Increased risk of cardiovascular events
Drug Interactions
- Magnesium-containing products may increase risk of hypermagnesemia
- Thiazide diuretics may increase risk of hypercalcemia
- Phosphate binding agents may decrease efficacy
Curated Content: Needs Vetting Before Put to Clinical Use