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chlortetracycline

J01AA03

Forms & Strengths

Ophthalmic Ointment: 1%
Topical Ointment: 3%

Adult Dosing

Ophthalmic: Apply a small amount (approx 1 cm) to the conjunctival sac of the affected eye(s) 2 to 4 times daily.
Topical: Apply a small amount to the affected area 1 to 4 times daily.

Pediatric Dosing

Ophthalmic (Neonates/Pediatrics): Apply a small amount to the conjunctival sac 2 to 4 times daily.
Topical (Pediatrics): Apply a small amount to the affected area 1 to 4 times daily as directed.

Indications

Treatment of superficial ocular infections involving the conjunctiva and/or cornea caused by susceptible organisms
Treatment of superficial skin infections and minor abrasions caused by susceptible bacteria

Mechanism of Action

Inhibits bacterial protein synthesis by reversibly binding to the 30S ribosomal subunit
Prevents access of aminoacyl-tRNA to the mRNA-ribosome complex, halting peptide chain elongation
Exerts primarily bacteriostatic activity against a wide range of gram-positive and gram-negative bacteria

Contraindications

Hypersensitivity to chlortetracycline or any tetracycline-class antibiotic
Viral or fungal diseases of the cornea and conjunctiva (for ophthalmic preparations)
History of hypersensitivity reactions to excipients in the formulation

Adverse Reactions

Transient stinging or burning upon application
Blurred vision temporarily following ophthalmic administration
Local hypersensitivity reactions including pruritus, rash, and contact dermatitis
Superinfection with nonsusceptible organisms, including fungi, with prolonged use

Drug Interactions

Topical application minimizes systemic absorption and clinically significant drug interactions
Concurrent use of other topical ocular or cutaneous products in the same area should be separated by at least 10-15 minutes

Curated Content: Needs Vetting Before Put to Clinical Use