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lymecycline

J01AA04

Forms & Strengths

Capsules: 300 mg (equivalent to 150 mg tetracycline base)

Adult Dosing

Acne vulgaris: 300 mg once daily, taken in the morning, for at least 8-12 weeks
Standard infections: 300 mg twice daily; may be increased to 600 mg twice daily in severe infections

Pediatric Dosing

Children > 8 years: 150 mg to 300 mg daily, depending on the severity of the infection
Not recommended in children under 8 years of age due to risk of permanent tooth discoloration and enamel hypoplasia

Indications

Acne vulgaris (moderate to severe)
Respiratory tract infections
Urinary tract infections
Non-gonococcal urethritis

Mechanism of Action

Binds reversibly to the 30S ribosomal subunit of susceptible organisms
Inhibits bacterial protein synthesis by preventing access of aminoacyl-tRNA to the mRNA-ribosome complex
Exhibits bacteriostatic activity against a wide range of Gram-positive and Gram-negative bacteria

Contraindications

Hypersensitivity to lymecycline or other tetracycline antibiotics
Pregnancy (second and third trimesters)
Breastfeeding
Children under 8 years of age
Severe hepatic impairment

Adverse Reactions

Nausea, abdominal pain, diarrhea
Headache, dizziness
Photosensitivity reactions
Hypersensitivity reactions including rash and urticaria
Vaginal candidiasis

Drug Interactions

Antacids, iron preparations, calcium, magnesium, and aluminum salts impair absorption (separate administration by at least 2 hours)
Enhances the anticoagulant effect of vitamin K antagonists (e.g., warfarin)
May reduce the efficacy of oral contraceptives
Concomitant use with retinoids increases the risk of intracranial hypertension

Curated Content: Needs Vetting Before Put to Clinical Use