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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › TETRACYCLINES › Tetracyclines
rolitetracycline
J01AA09
Forms & Strengths
- Injectable powder for reconstitution: 150 mg
- Injectable powder for reconstitution: 350 mg
Adult Dosing
- Intravenous infusion: 150 mg to 350 mg every 12 hours
- Maximum daily dose: 700 mg
Pediatric Dosing
- Safety and efficacy not established in children under 8 years of age
- Children over 8 years: 10 mg/kg to 20 mg/kg daily divided in two doses, restricted to severe infections
Indications
- Treatment of severe infections caused by susceptible gram-positive and gram-negative bacteria
- Alternative to oral tetracyclines when oral route is not feasible
Mechanism of Action
- Inhibits bacterial protein synthesis by reversibly binding to the 30S ribosomal subunit
- Prevents access of aminoacyl-tRNA to the mRNA-ribosome complex
Contraindications
- Hypersensitivity to rolitetracycline or other tetracycline antibiotics
- Severe hepatic impairment
- Pregnancy during the second and third trimesters
- Children under 8 years of age due to risk of permanent tooth discoloration and enamel hypoplasia
Adverse Reactions
- Injection site thrombophlebitis and pain
- Nausea, vomiting, and diarrhea
- Photosensitivity and skin rashes
- Transient elevation of liver function tests
- Superinfections including candidiasis and pseudomembranous colitis
Drug Interactions
- May decrease the efficacy of oral contraceptives
- Enhances the anticoagulant effect of warfarin
- Concomitant use with methoxyflurane may result in fatal nephrotoxicity
- Bacteriostatic action may interfere with the bactericidal activity of penicillins
Curated Content: Needs Vetting Before Put to Clinical Use