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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › TETRACYCLINES › Tetracyclines
sarecycline
J01AA14
Forms & Strengths
- Oral tablets: 60 mg
- Oral tablets: 100 mg
Adult Dosing
- Weight 33 kg to 54 kg: 60 mg orally once daily
- Weight 55 kg to 84 kg: 100 mg orally once daily
- Weight 85 kg to 136 kg: 150 mg orally once daily
Pediatric Dosing
- Children < 9 years: Safety and efficacy not established
- Pediatric patients 9 years and older: Dosed by weight mirroring adult weight-based tiers
Indications
- Treatment of inflammatory lesions of non-nodular moderate to severe acne vulgaris
Mechanism of Action
- Tetracycline-class antimicrobial; exerts anti-inflammatory and antibacterial effects via inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit
Contraindications
- Known hypersensitivity to any tetracyclines
Adverse Reactions
- Nausea
- Nasopharyngitis
- Vomiting
- Headache
Drug Interactions
- Antacids, polyvalent cation-containing products, and iron preparations may decrease absorption of tetracyclines
- May potentiate the anticoagulant effect of warfarin
- May diminish the efficacy of penicillin-class drugs
Curated Content: Needs Vetting Before Put to Clinical Use