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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › BETA-LACTAM ANTIBACTERIALS, PENICILLINS › Penicillins with extended spectrum
bacampicillin
J01CA06
Adult Dosing
- Upper respiratory tract infections: 400 mg to 800 mg orally every 12 hours
- Lower respiratory tract infections: 800 mg orally every 12 hours
- Urinary tract infections: 400 mg to 800 mg orally every 12 hours
- Skin and skin structure infections: 400 mg to 800 mg orally every 12 hours
Pediatric Dosing
- Children > 25 kg: Dosed similarly to adults based on infection severity and weight
- Children < 25 kg: 25 mg/kg to 50 mg/kg/day divided in 12-hour doses
Indications
- Upper respiratory tract infections caused by susceptible organisms
- Lower respiratory tract infections caused by susceptible organisms
- Urinary tract infections caused by susceptible organisms
- Skin and skin structure infections caused by susceptible organisms
Mechanism of Action
- Prodrug of ampicillin; rapidly hydrolyzed in the intestinal wall during absorption to release active ampicillin
- Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and death
Contraindications
- Known hypersensitivity to penicillins or any component of the formulation
- History of penicillin-associated cholestatic jaundice or hepatic dysfunction
Adverse Reactions
- Diarrhea and loose stools
- Nausea and vomiting
- Rash (maculopapular and urticarial)
- Superinfections (including oral and vaginal candidiasis)
- Clostridium difficile-associated diarrhea
Drug Interactions
- Probenecid decreases renal tubular secretion of ampicillin, increasing serum concentrations
- Allopurinol co-administration increases the incidence of skin rashes
- May reduce the efficacy of oral contraceptives via enterohepatic circulation disruption
Curated Content: Needs Vetting Before Put to Clinical Use