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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › BETA-LACTAM ANTIBACTERIALS, PENICILLINS › Penicillins with extended spectrum
pivmecillinam
J01CA08
Forms & Strengths
- Tablets: 200mg
- Oral suspension: 100mg/5ml
Adult Dosing
- 400mg twice daily
- Treatment duration: 5-10 days
Pediatric Dosing
- 20-40mg/kg/day in 2 divided doses
- Maximum dose: 400mg twice daily
- Age >3 months: oral suspension preferred
Indications
- Uncomplicated urinary tract infections
- Acute cystitis
- Acute pyelonephritis
Mechanism of Action
- Inhibits bacterial cell wall synthesis
- Interferes with transpeptidation process
- Bactericidal action against Gram-negative bacteria
Contraindications
- Hypersensitivity to pivmecillinam or mecillinam
- Previous history of penicillin or carbapenem allergy
Adverse Reactions
- Gastrointestinal disturbances
- Diarrhea
- Nausea and vomiting
- Hypersensitivity reactions: rash, urticaria, anaphylaxis
Drug Interactions
- Warfarin: enhances anticoagulant effect
- Methotrexate: increases toxicity
- Inhibits the renal excretion of methotrexate
Curated Content: Needs Vetting Before Put to Clinical Use