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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › BETA-LACTAM ANTIBACTERIALS, PENICILLINS › Penicillins with extended spectrum
temocillin
J01CA17
Forms & Strengths
- Temocillin is available as disodium temocillin
- Powder for injection 1g or 2g
- Reconstituted solutions for intravenous or intramuscular injection
Adult Dosing
- Usual dose: 1-2g every 12 hours
- Severe infections: 2g every 8-12 hours
- Renal impairment: dose adjustments required
Pediatric Dosing
- Limited data available
- Neonates and infants: not recommended due to lack of data
- Children over 1 year: dose adjusted according to age and weight
Indications
- Temocillin is used to treat infections caused by Gram-negative aerobic bacteria
- Including infections of the urinary tract, skin, and soft tissues
- Pneumonia, intra-abdominal infections, and septicemia
Mechanism of Action
- Temocillin is a beta-lactam antibiotic
- Works by inhibiting bacterial cell wall synthesis
- Resistant to beta-lactamase degradation
Contraindications
- Hypersensitivity to temocillin or other beta-lactam antibiotics
- History of allergic reactions to beta-lactams, such as penicillins or cephalosporins
Adverse Reactions
- Gastrointestinal disturbances, including diarrhea and nausea
- Allergic reactions, including rash, pruritus, and anaphylaxis
- Hepatic dysfunction and renal impairment
Drug Interactions
- Concomitant use with other nephrotoxic agents may increase risk of renal impairment
- Interaction with aminoglycosides may increase risk of nephrotoxicity
- Concomitant use with probenecid may increase temocillin concentrations
Curated Content: Needs Vetting Before Put to Clinical Use