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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › BETA-LACTAM ANTIBACTERIALS, PENICILLINS › Beta-lactamase sensitive penicillins
azidocillin
J01CE04
Forms & Strengths
- Capsules: 200mg, 400mg, 600mg
- Tablets: 400mg
- Powder for injection: 500mg, 1g
Adult Dosing
- Typical dose: 400mg to 600mg every 6 hours
- Severe infections: 800mg to 1.2g every 6 hours
- Renal impairment: adjust dose based on creatinine clearance
Pediatric Dosing
- Children over 12 years: same as adult dose
- Children 6-12 years: 200mg to 400mg every 6-8 hours
- Children under 6 years: not recommended
Indications
- Treatment of bacterial infections
- Pneumonia
- Skin and soft tissue infections
- Urinary tract infections
Mechanism of Action
- Inhibits bacterial cell wall synthesis
- Interferes with transpeptidation process
- Bactericidal effect
Contraindications
- Hypersensitivity to penicillins
- Severe renal impairment
- History of allergic reactions to beta-lactams
Adverse Reactions
- Gastrointestinal disturbances
- Allergic reactions
- Hepatotoxicity
- Neurotoxicity with high doses
Drug Interactions
- Probencid: increases azidocillin levels
- Warfarin: increases anticoagulant effect
- Methotrexate: increases toxicity
Curated Content: Needs Vetting Before Put to Clinical Use