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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › BETA-LACTAM ANTIBACTERIALS, PENICILLINS › Combinations of penicillins, incl. beta-lactamase inhibitors
ticarcillin and beta-lactamase inhibitor
J01CR03
Forms & Strengths
- Injection: 3g ticarcillin and 100mg clavulanic acid per 10mL
- Injection: 3.1g ticarcillin and 100mg clavulanic acid per 10mL
- Powder for solution: 3g ticarcillin and 100mg clavulanic acid per vial
Adult Dosing
- 3.1g IV every 4-6 hours for urinary tract infections
- 3.1g IV every 4-6 hours for lower respiratory tract infections
- 3.1g IV every 6 hours for skin and skin structure infections
- 4.5g IV every 6 hours for intra-abdominal infections
Pediatric Dosing
- 50-75mg/kg/day IV divided every 6-8 hours for pediatric patients >3 months
- Use with caution in pediatric patients with renal impairment
- Dosage adjustment may be necessary in pediatric patients with hepatic impairment
Indications
- Treatment of urinary tract infections caused by susceptible organisms
- Treatment of lower respiratory tract infections caused by susceptible organisms
- Treatment of skin and skin structure infections caused by susceptible organisms
- Treatment of intra-abdominal infections caused by susceptible organisms
Mechanism of Action
- Ticarcillin inhibits cell wall synthesis by binding to penicillin-binding proteins
- Clavulanic acid inhibits beta-lactamase enzymes, protecting ticarcillin from degradation
- Combination provides broad-spectrum antibacterial activity
Contraindications
- Hypersensitivity to ticarcillin, clavulanic acid, or other penicillins
- History of cholestatic jaundice or hepatic dysfunction associated with ticarcillin/clavulanic acid
Adverse Reactions
- Diarrhea, nausea, vomiting, and abdominal pain are common
- Hypersensitivity reactions, including anaphylaxis and serum sickness-like reactions, can occur
- Clostridioides difficile-associated diarrhea and colitis can occur
Drug Interactions
- Probencid decreases renal clearance of ticarcillin, increasing its efficacy and risk of toxicity
- Concomitant use with aminoglycosides may increase risk of nephrotoxicity
- Ticarcillin/clavulanic acid may decrease efficacy of oral contraceptives
Curated Content: Needs Vetting Before Put to Clinical Use