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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › OTHER BETA-LACTAM ANTIBACTERIALS › First-generation cephalosporins
cefatrizine
J01DB07
Forms & Strengths
- Tablets: 250mg, 500mg
- Capsules: 250mg, 500mg
- Powder for oral suspension: 125mg/5mL, 250mg/5mL
Adult Dosing
- 250-500mg every 8-12 hours
- Severe infections: 500mg every 6-8 hours
Pediatric Dosing
- 12 years and older: 250-500mg every 8-12 hours
- 6-11 years: 250mg every 8-12 hours
- Under 6 years: 10-20mg/kg/day divided every 8 hours
Indications
- Uncomplicated urinary tract infections
- Otitis media
- Pharyngitis
- Bronchitis
- Skin and soft tissue infections
Mechanism of Action
- Inhibits bacterial cell wall synthesis
- Interferes with transpeptidation and transglycosylation
- Binds to penicillin-binding proteins
Contraindications
- Hypersensitivity to cefatrizine or other cephalosporins
- Severe penicillin allergy
Adverse Reactions
- Diarrhea
- Nausea
- Vomiting
- Abdominal pain
- Hypersensitivity reactions
- Clostridioides difficile associated diarrhea
Drug Interactions
- Decreased efficacy with concurrent use of bacteriostatic agents
- Increased nephrotoxicity with aminoglycosides
- Increased risk of bleeding with anticoagulants
Curated Content: Needs Vetting Before Put to Clinical Use