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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › OTHER BETA-LACTAM ANTIBACTERIALS › First-generation cephalosporins
cefroxadine
J01DB11
Forms & Strengths
- Oral capsules: 250 mg
- Oral suspension: 250 mg/5 mL
Adult Dosing
- General infections: 500 mg to 1 g orally every 8 to 12 hours
- Maximum daily dose: 4 g daily
Pediatric Dosing
- Children (>1 month): 25 to 50 mg/kg/day orally divided in 3 doses
- Severe infections: up to 100 mg/kg/day orally in divided doses
Indications
- Respiratory tract infections caused by susceptible organisms
- Urinary tract infections
- Skin and soft tissue infections
Mechanism of Action
- Inhibition of bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs)
- Bactericidal activity against susceptible gram-positive and limited gram-negative bacteria
Contraindications
- Hypersensitivity to cefroxadine, other cephalosporins, or beta-lactam antibiotics
Adverse Reactions
- Gastrointestinal: Diarrhea, nausea, vomiting, abdominal pain
- Hypersensitivity: Rash, urticaria, pruritus, fever
- Hematologic: Eosinophilia, transient neutropenia
- Hepatic: Transient elevation of liver transaminases
Drug Interactions
- Probenecid: Decreases renal tubular secretion of cephalosporins, increasing serum concentrations
- Aminoglycosides: Potential for additive nephrotoxicity
- Oral anticoagulants: May enhance the effects of coumarin derivatives by reducing vitamin K-producing gut flora
Curated Content: Needs Vetting Before Put to Clinical Use