← Search & browse all drugs
ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › OTHER BETA-LACTAM ANTIBACTERIALS › Second-generation cephalosporins
flomoxef
J01DC14
Forms & Strengths
- 500mg and 1000mg capsules and intravenous injection
- 250mg and 500mg powder for injection
Adult Dosing
- 250-1000mg every 8-12 hours for 7-14 days for uncomplicated infections
- 500-1000mg every 8-12 hours for 10-14 days for complicated infections
- 1000mg every 8 hours for severe infections
Pediatric Dosing
- 20-40mg/kg/day in 2-4 divided doses for children over 1 month of age
- 10-20mg/kg/day in 2-4 divided doses for children under 1 month of age
- maximum dose: 500mg/dose
Indications
- uncomplicated urinary tract infections
- complicated urinary tract infections
- pneumonia
- skin and soft tissue infections
Mechanism of Action
- inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins
- interferes with peptidoglycan synthesis
- exhibits bactericidal activity against susceptible organisms
Contraindications
- hypersensitivity to flomoxef or other oxacephem antibiotics
- severe renal impairment
- history of cephalosporin or carbapenem allergy
Adverse Reactions
- gastrointestinal upset (nausea, vomiting, diarrhea)
- allergic reactions (rash, urticaria, pruritus)
- hepatic enzyme elevation
- hematologic changes (leukopenia, thrombocytopenia)
Drug Interactions
- co-administration with probenecid increases flomoxef serum concentrations
- concomitant use with aminoglycosides may increase nephrotoxicity risk
- caution when using with other nephrotoxic agents
Curated Content: Needs Vetting Before Put to Clinical Use