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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › OTHER BETA-LACTAM ANTIBACTERIALS › Third-generation cephalosporins
cefixime
J01DD08
Forms & Strengths
- Oral suspension: 100 mg/5 mL, 200 mg/5 mL
- Tablet: 400 mg
- Chewable tablet: 100 mg, 200 mg
Adult Dosing
- Uncomplicated urinary tract infections: 400 mg orally once daily or 200 mg orally every 12 hours for 7-14 days
- Gonococcal infections (uncomplicated cervical/urethral/rectal): 400 mg orally as a single dose
- Acute exacerbation of chronic bronchitis: 400 mg orally once daily or 200 mg every 12 hours for 10 days
Pediatric Dosing
- Children 6 months to 12 years: 8 mg/kg/day orally once daily or divided as 4 mg/kg every 12 hours
- Otitis media: 8 mg/kg/day orally once daily or 4 mg/kg every 12 hours for 10 days
Indications
- Uncomplicated urinary tract infections caused by E. coli and P. mirabilis
- Otitis media caused by H. influenzae, M. catarrhalis, and S. pyogenes
- Pharyngitis and tonsillitis caused by S. pyogenes
- Acute exacerbations of chronic bronchitis caused by S. pneumoniae, H. influenzae, and M. catarrhalis
- Uncomplicated gonococcal infections caused by N. gonorrhoeae
Mechanism of Action
- Third-generation cephalosporin that inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), leading to cell lysis and death
Contraindications
- Hypersensitivity to cefixime or other cephalosporin-class antibiotics
Adverse Reactions
- Diarrhea
- Stool changes
- Abdominal pain
- Nausea
- Dyspepsia
- Flatulence
- Headache
- Dizziness
Drug Interactions
- Carbamazepine: May increase carbamazepine levels and toxicity
- Anticoagulants (warfarin): May increase prothrombin time and bleeding risk
Curated Content: Needs Vetting Before Put to Clinical Use