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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › OTHER BETA-LACTAM ANTIBACTERIALS › Third-generation cephalosporins
cefpiramide
J01DD11
Forms & Strengths
- Injectable powder for reconstitution: 1 g, 2 g
Adult Dosing
- General infections: 1 g to 2 g IV or IM every 12 hours
- Severe or refractory infections: Up to 4 g daily divided in 2 doses
Pediatric Dosing
- Safety and efficacy in pediatric patients not fully established; use determined by specialist clinical judgment
Indications
- Respiratory tract infections
- Urinary tract infections
- Intra-abdominal infections
- Biliary tract infections
- Skin and skin structure infections
- Sepsis caused by susceptible gram-negative and gram-positive bacteria
Mechanism of Action
- Third-generation cephalosporin with broad-spectrum bactericidal activity
- Inhibits bacterial cell wall synthesis by binding to one or more penicillin-binding proteins (PBPs)
- Particularly noted for enhanced biliary excretion and activity against Pseudomonas aeruginosa
Contraindications
- Known hypersensitivity to cefpiramide, other cephalosporins, or beta-lactam antibiotics
- History of severe immediate hypersensitivity reactions (e.g., anaphylaxis) to penicillins
Adverse Reactions
- Hypersensitivity reactions (rash, pruritus, urticaria)
- Gastrointestinal effects (diarrhea, nausea, pseudomembranous colitis)
- Hepatic transient elevation of liver enzymes (AST, ALT, ALP)
- Hematologic changes (eosinophilia, thrombocytopenia, hypoprothrombinemia)
- Injection site reactions (pain, phlebitis)
Drug Interactions
- Aminoglycosides: Potential for synergistic nephrotoxicity
- Anticoagulants (warfarin): May increase bleeding risk due to possible hypoprothrombinemia and inhibition of vitamin K synthesis
- Alcohol: Disulfiram-like reaction (flushing, tachycardia, nausea) due to N-methylthiotetrazole side chain
Curated Content: Needs Vetting Before Put to Clinical Use