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cefteram

J01DD18

Forms & Strengths

Oral tablets: 50 mg
Oral tablets: 100 mg
Fine granules for oral suspension: 10% (100 mg/g)

Adult Dosing

Standard oral dose: 100 mg to 150 mg three times daily
Complicated infections or severe cases: up to 200 mg three times daily
Administer after meals to improve gastrointestinal tolerance

Pediatric Dosing

Children oral dose: 3 mg/kg to 6 mg/kg per dose administered three times daily
Maximum daily pediatric dose should not exceed standard adult limits adjusted for weight
Safety and efficacy in neonates and premature infants not fully established

Indications

Pharyngitis and tonsillitis
Acute bronchitis and pneumonia
Otitis media and sinusitis
Urinary tract infections caused by susceptible organisms

Mechanism of Action

Third-generation cephalosporin antibiotic acting as a bactericidal agent
Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs)
Displays broad-spectrum activity against many Gram-positive and Gram-negative aerobic bacteria

Contraindications

Known hypersensitivity to cefteram or other cephalosporin-class antibiotics
History of immediate or severe hypersensitivity reactions (e.g., anaphylaxis) to penicillins or other beta-lactams

Adverse Reactions

Gastrointestinal: diarrhea, loose stools, nausea, abdominal pain
Hypersensitivity: rash, urticaria, pruritus
Hepatic: transient elevations in AST, ALT, and ALP
Hematological: transient eosinophilia, rare leukopenia

Drug Interactions

Probenecid decreases renal tubular secretion of cephalosporins, leading to increased and prolonged blood concentrations
Antacids and H2-receptor antagonists may alter oral absorption kinetics if co-administered simultaneously
May enhance the anticoagulant effect of vitamin K antagonists (warfarin) by altering gut flora synthesis of vitamin K

Curated Content: Needs Vetting Before Put to Clinical Use