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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › OTHER BETA-LACTAM ANTIBACTERIALS › Carbapenems
doripenem
J01DH04
Forms & Strengths
- Powder for injection 250mg
- Powder for injection 500mg
Adult Dosing
- 500mg IV every 8 hours for complicated intra-abdominal infections
- 500mg IV every 8 hours for complicated urinary tract infections
- 250-500mg IV every 8 hours for pyelonephritis
Pediatric Dosing
- 20-40mg/kg/dose IV every 8 hours, not to exceed 500mg/dose for complicated intra-abdominal infections (ages 12-17)
- Usage in pediatric patients is not well established
Indications
- Complicated intra-abdominal infections
- Complicated urinary tract infections, including pyelonephritis
Mechanism of Action
- Inhibits bacterial cell wall synthesis
- Binds to penicillin-binding proteins
- Interferes with peptidoglycan synthesis
Contraindications
- Hypersensitivity to doripenem or other carbapenems
- Hypersensitivity to any component of the product
Adverse Reactions
- Nausea
- Diarrhea
- Headache
- Rash
- Pruritus
- Hypersensitivity reactions (e.g., anaphylaxis, Stevens-Johnson syndrome)
Drug Interactions
- Probenecid: decreases renal clearance of doripenem
- Valproic acid: decreases serum concentration of valproic acid
- Concurrent use with other antibiotics may increase risk of seizures
Curated Content: Needs Vetting Before Put to Clinical Use