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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › OTHER BETA-LACTAM ANTIBACTERIALS › Other cephalosporins and penems
ceftaroline fosamil
J01DI02
Forms & Strengths
- 600mg/vial powder for injection
- 400mg/vial powder for injection
- 600mg single-dose pre-filled syringe
Adult Dosing
- 600mg every 12 hours for CAP, ABSSSI
- 600mg every 8 hours for S. aureus bacteremia
- Dose adjustments for renal impairment
Pediatric Dosing
- For children 2 months to less than 18 years: 8mg/kg/dose every 8 hours for ABSSSI, CAP
- For children 2 months to less than 18 years: 12mg/kg/dose every 8 hours for HABP, VABP
- Maximum dose not to exceed 600mg
Indications
- Community-acquired pneumonia (CAP)
- Acute bacterial skin and skin structure infections (ABSSSI)
- Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VABP)
Mechanism of Action
- Ceftaroline binds to and inhibits penicillin-binding proteins
- Resulting in reduced bacterial cell wall synthesis
- It has bactericidal activity against gram-positive and gram-negative bacteria
Contraindications
- Hypersensitivity to ceftaroline or other cephalosporins
- Severe hypersensitivity to penicillins
Adverse Reactions
- Nausea, diarrhea, headache, infusion-related reactions
- Increased liver enzymes, thrombocytosis
- Hypersensitivity, anaphylaxis (rare)
Drug Interactions
- May decrease efficacy of tobramycin
- May increase INR when co-administered with warfarin
- Not recommended to use with chloramphenicol
Curated Content: Needs Vetting Before Put to Clinical Use