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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › OTHER BETA-LACTAM ANTIBACTERIALS › Other cephalosporins and penems
cefiderocol
J01DI04
Forms & Strengths
- 1g powder for injection, single-dose vial
- injection: 1g/10mL, 1g/20mL
Adult Dosing
- 2g IV every 8 hours for 8-14 days for complicated urinary tract infections
- 2g IV every 8 hours for 7-14 days for hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia
Pediatric Dosing
- safety and efficacy not established in pediatric patients
- no dosing recommendations are available
Indications
- complicated urinary tract infections, including pyelonephritis
- hospital-acquired bacterial pneumonia, ventilator-associated bacterial pneumonia
Mechanism of Action
- cephalosporin antibiotic, inhibits cell wall synthesis by binding to penicillin-binding proteins
- has a unique mechanism of entry into bacterial cells, utilizing siderophore-based iron transport system
Contraindications
- hypersensitivity to cefiderocol or other cephalosporins
- anaphylactic reaction to cefiderocol or other beta-lactam antibiotics
Adverse Reactions
- diarrhea, nausea, vomiting, constipation, headache
- increased liver enzymes, infusion-related reactions, rash, pruritus
Drug Interactions
- co-administration with iron supplements, multivitamins may reduce efficacy
- not metabolized by cytochrome P450 enzymes, minimal potential for interactions
Curated Content: Needs Vetting Before Put to Clinical Use