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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › SULFONAMIDES AND TRIMETHOPRIM › Short-acting sulfonamides
sulfaisodimidine
J01EB01
Forms & Strengths
- Tablets: 500mg
- Injectable: 1g/5mL
- Oral suspension: 250mg/5mL
Adult Dosing
- UTI: 1g every 12 hours for 10-14 days
- Acute prostatitis: 2g every 12 hours for 10-14 days
- Uncomplicated gonorrhea: 2g single dose
Pediatric Dosing
- Children over 12 years: same as adult dose
- Children 6-12 years: 30-50mg/kg/day in 2 divided doses
- Children under 6 years: not recommended
Indications
- Urinary tract infections
- Acute prostatitis
- Uncomplicated gonorrhea
- Chancroid
- Inclusion conjunctivitis
Mechanism of Action
- Inhibits folic acid synthesis in bacteria
- Competitively inhibits dihydropteroate synthase
- Prevents bacterial DNA synthesis
Contraindications
- Hypersensitivity to sulfonamides
- Pregnancy at term
- Infancy under 2 months
- Severe liver or kidney disease
Adverse Reactions
- Nausea and vomiting
- Diarrhea
- Headache
- Dizziness
- Allergic reactions: rash, fever, agranulocytosis
Drug Interactions
- Potentiated by probenecid
- Antagonized by PABA
- Increased risk of crystalluria with methoxyflurane
- Increased risk of kernicterus with indirect bilirubin
Curated Content: Needs Vetting Before Put to Clinical Use