← Search & browse all drugs
ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › SULFONAMIDES AND TRIMETHOPRIM › Long-acting sulfonamides
sulfametoxydiazine
J01ED04
Forms & Strengths
- Tablets: 500mg
- Suspension: 250mg/5mL
Adult Dosing
- UTIs: 1g every 12 hours for 10-14 days
- Acute prostatitis: 1g every 12 hours for 14-28 days
Pediatric Dosing
- Children over 12 years: same as adult dose
- Children under 12 years: not recommended
Indications
- Uncomplicated urinary tract infections
- Acute prostatitis
- Complicated urinary tract infections
Mechanism of Action
- Inhibits folic acid synthesis in bacteria
- Bacteriostatic at low concentrations, bactericidal at high concentrations
Contraindications
- Hypersensitivity to sulfonamides
- Pregnancy at term or during breastfeeding
- Infants under 2 months
Adverse Reactions
- Nausea and vomiting
- Dizziness and headache
- Allergic reactions: rash, itching, anaphylaxis
Drug Interactions
- Warfarin: increased anticoagulant effect
- Methotrexate: increased toxicity
- Phenytoin: decreased phenytoin levels
Curated Content: Needs Vetting Before Put to Clinical Use