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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS › Macrolides
oleandomycin
J01FA05
Forms & Strengths
- Oral capsule 250 mg
- Intravenous injection 500 mg vial
Adult Dosing
- Oral: 250 mg to 500 mg every 6 hours
- Intravenous: 500 mg every 6 to 12 hours for severe infections
Pediatric Dosing
- Oral: 30 mg/kg/day divided every 6 hours
- Intravenous: 15 to 30 mg/kg/day divided every 8 to 12 hours
Indications
- Treatment of susceptible Gram-positive bacterial infections
- Alternative for penicillin-allergic patients with mild to moderate respiratory tract infections
Mechanism of Action
- Binds to the 50S ribosomal subunit of susceptible bacteria
- Inhibits bacterial protein synthesis and cell growth (bacteriostatic)
Contraindications
- Known hypersensitivity to oleandomycin or macrolide antibiotics
- Pre-existing hepatic dysfunction or jaundice associated with prior macrolide use
Adverse Reactions
- Nausea, vomiting, abdominal discomfort, diarrhea
- Transient elevations in liver transaminases
- Hypersensitivity reactions including rash and urticaria
Drug Interactions
- Inhibition of CYP3A4 may increase serum levels of statins, carbamazepine, and theophylline
- Potential prolongation of QT interval when co-administered with other QT-prolonging drugs
Curated Content: Needs Vetting Before Put to Clinical Use