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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS › Macrolides
troleandomycin
J01FA08
Forms & Strengths
- 250mg tablets
- 250mg capsules
Adult Dosing
- 250-500mg every 6 hours
- Maximum dose: 4g/day
Pediatric Dosing
- 12.5-25mg/kg/day divided every 6 hours
- Maximum dose: 50mg/kg/day or 2g/day, whichever is less
Indications
- Pneumonia caused by Streptococcus pneumoniae
- Bronchitis caused by Haemophilus influenzae
- Infections caused by Staphylococcus aureus
Mechanism of Action
- Inhibits protein synthesis by binding to 50S ribosomal subunit
- Bacteriostatic at low concentrations, bactericidal at high concentrations
Contraindications
- Hypersensitivity to troleandomycin or macrolides
- Concomitant use with terfenadine, cisapride, or pimozide
Adverse Reactions
- Gastrointestinal upset
- Allergic reactions (rash, urticaria, anaphylaxis)
- Hepatotoxicity (elevated liver enzymes, jaundice)
Drug Interactions
- Increased theophylline levels
- Increased digoxin levels
- Decreased efficacy of warfarin
Curated Content: Needs Vetting Before Put to Clinical Use