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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS › Streptogramins
pristinamycin
J01FG01
Forms & Strengths
- Tablets: 250mg, 500mg
- Injectable: 500mg/vial, 1g/vial
Adult Dosing
- 500mg to 1g every 6 hours
- Severe infections: 1g every 6 hours
- Mild to moderate infections: 250mg to 500mg every 6 hours
Pediatric Dosing
- Children over 8 years: 12.5mg/kg every 6 hours
- Children under 8 years: not recommended
Indications
- Treatment of infections caused by Gram-positive bacteria
- Treatment of pneumonia caused by Streptococcus pneumoniae
- Treatment of skin and soft tissue infections
Mechanism of Action
- Inhibits protein synthesis by binding to bacterial ribosomes
- Streptogramin antibiotic with bacteriostatic activity
Contraindications
- Hypersensitivity to pristinamycin or other streptogramins
- Pregnancy and lactation: use with caution
Adverse Reactions
- Gastrointestinal disturbances
- Allergic reactions
- Hepatotoxicity
- Nephrotoxicity
Drug Interactions
- May interact with other antibiotics
- May interact with cyclosporine and other nephrotoxic drugs
- Concomitant use with other hepatotoxic drugs may increase risk of hepatotoxicity
Curated Content: Needs Vetting Before Put to Clinical Use