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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › AMINOGLYCOSIDE ANTIBACTERIALS › Other aminoglycosides
plazomicin
J01GB14
Forms & Strengths
- 15mg/mL single-dose vial for IV injection
Adult Dosing
- 15mg/kg every 24 hours for complicated UTI
- Dose adjustment required for renal impairment
Pediatric Dosing
- Safety and efficacy not established for pediatric use
Indications
- Complicated urinary tract infections (cUTI)
- Acute pyelonephritis
Mechanism of Action
- Aminoglycoside antibiotic that inhibits bacterial protein synthesis
- Binds to 30S ribosomal subunit, interfering with translation
Contraindications
- Hypersensitivity to plazomicin or other aminoglycosides
Adverse Reactions
- Nephrotoxicity
- Ototoxicity
- Neuromuscular blockade
- Anaphylaxis
Drug Interactions
- Nephrotoxic agents (e.g. NSAIDs, vancomycin) may increase risk of nephrotoxicity
- Ototoxic agents (e.g. loop diuretics) may increase risk of ototoxicity
Curated Content: Needs Vetting Before Put to Clinical Use