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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › QUINOLONE ANTIBACTERIALS › Fluoroquinolones
ciprofloxacin
J01MA02
Forms & Strengths
- Tablets: 250mg, 500mg, 750mg
- Oral suspension: 250mg/5mL, 500mg/5mL
- IV solution: 200mg/100mL, 400mg/200mL
- Ophthalmic solution: 0.3%
- Otic solution: 0.2%
Adult Dosing
- Uncomplicated urinary tract infections: 250mg every 12 hours for 3 days
- Complicated urinary tract infections: 500mg every 12 hours for 7-14 days
- Respiratory tract infections: 500-750mg every 12 hours for 7-14 days
- Skin and skin structure infections: 500-750mg every 12 hours for 7-14 days
Pediatric Dosing
- Inhalational anthrax: 15mg/kg every 12 hours for 60 days
- Complicated urinary tract infections: 10-20mg/kg every 12 hours for 10-21 days
- Pediatric dosing should not exceed adult dosing
Indications
- Urinary tract infections
- Respiratory tract infections
- Skin and skin structure infections
- Bone and joint infections
- Inhalational anthrax
- Gonorrhea
Mechanism of Action
- Inhibits bacterial DNA gyrase and topoisomerase IV
- Interferes with bacterial DNA replication and transcription
Contraindications
- Hypersensitivity to ciprofloxacin or other fluoroquinolones
- Concomitant use with tizanidine
- Pregnancy and lactation
Adverse Reactions
- Nausea and vomiting
- Diarrhea
- Abdominal pain
- Rash
- Headache
- Dizziness
- Tendinitis and tendon rupture
Drug Interactions
- Theophylline: increased theophylline levels
- Warfarin: increased INR
- Phenytoin: increased phenytoin levels
- Caffeine: increased caffeine levels
- Antacids: decreased ciprofloxacin absorption
Curated Content: Needs Vetting Before Put to Clinical Use