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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › QUINOLONE ANTIBACTERIALS › Fluoroquinolones
enoxacin
J01MA04
Forms & Strengths
- Oral tablets: 200 mg
- Oral tablets: 400 mg
Adult Dosing
- Uncomplicated urinary tract infections: 200 mg orally every 12 hours for 7 days
- Complicated urinary tract infections: 400 mg orally every 12 hours for 14 days
- Gonorrhea (uncomplicated): 400 mg orally as a single dose
- Renal adjustment (CrCl < 30 mL/min): reduce dose by 50%
Pediatric Dosing
- Not recommended for pediatric patients under 18 years due to risk of arthropathy and cartilage damage
Indications
- Treatment of urinary tract infections caused by susceptible gram-negative and gram-positive organisms
- Treatment of uncomplicated gonococcal urethritis or cervicitis
Mechanism of Action
- Fluoroquinolone antibacterial agent
- Inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription
Contraindications
- Hypersensitivity to enoxacin, other quinolones, or excipients
- History of tendinitis or tendon rupture associated with fluoroquinolone use
- Concurrent administration with tizanidine
Adverse Reactions
- Nausea, vomiting, abdominal pain, diarrhea
- Headache, dizziness, insomnia, CNS stimulation
- Photosensitivity and rash
- Elevated liver enzymes
- Tendinitis and tendon rupture
- QT prolongation
Drug Interactions
- Theophylline: enoxacin significantly increases serum theophylline concentrations, leading to potential toxicity
- Caffeine: decreased clearance and increased neuro/cardiac toxicity of caffeine
- Antacids and sucralfate: divalent/trivalent cations significantly reduce enoxacin absorption
- Warfarin: enhanced anticoagulant effect and bleeding risk
- NSAIDs: increased risk of CNS stimulation and seizures
- QT-prolonging drugs: additive risk of arrhythmias
Curated Content: Needs Vetting Before Put to Clinical Use