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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › QUINOLONE ANTIBACTERIALS › Fluoroquinolones
trovafloxacin
J01MA13
Forms & Strengths
- Trovafloxacin 100mg, 200mg tablets
- Trovafloxacin 200mg/100mL IV solution
Adult Dosing
- 200-300mg IV or PO every 12-24 hours
- Dose adjustment for renal impairment: CrCl <50mL/min, 200mg IV or PO every 24 hours
Pediatric Dosing
- Safety and efficacy not established in pediatric patients
- Use with caution in adolescents, due to potential risk of cartilage damage
Indications
- Treatment of complicated and uncomplicated infections
- Skin and skin structure infections
- Respiratory tract infections
- Urinary tract infections
- Intra-abdominal infections
Mechanism of Action
- Inhibits bacterial DNA gyrase and topoisomerase IV
- Interferes with DNA replication, transcription, and repair
Contraindications
- Hypersensitivity to trovafloxacin or other fluoroquinolones
- Pregnancy and lactation
- Pediatric patients, except in life-threatening situations
Adverse Reactions
- Nausea, vomiting, diarrhea, abdominal pain
- Headache, dizziness, insomnia, seizures
- Rash, pruritus, photosensitivity, hepatotoxicity
- Renal dysfunction, QT interval prolongation
Drug Interactions
- CNS depressants: increased risk of seizures
- Theophylline: increased theophylline levels
- Warfarin: increased INR, risk of bleeding
- Didanosine: decreased trovafloxacin absorption
Curated Content: Needs Vetting Before Put to Clinical Use