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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › QUINOLONE ANTIBACTERIALS › Fluoroquinolones
pazufloxacin
J01MA18
Forms & Strengths
- 250mg and 500mg tablets
- 100mg and 500mg injectable solutions
Adult Dosing
- 250-500mg every 24 hours for 5-14 days for uncomplicated urinary tract infections
- 500mg every 24 hours for 5-14 days for complicated urinary tract infections and mild to moderate skin infections
- 500mg every 24 hours for 7-14 days for moderate to severe pneumonia
Pediatric Dosing
- safety and efficacy not established in patients under 18 years old
- use in pediatric patients only when benefits outweigh the risks
Indications
- uncomplicated urinary tract infections
- complicated urinary tract infections
- mild to moderate skin infections
- moderate to severe pneumonia
Mechanism of Action
- inhibits bacterial DNA gyrase and topoisomerase IV
- interferes with bacterial DNA replication and transcription
Contraindications
- hypersensitivity to pazufloxacin or other fluoroquinolones
- pregnancy and lactation
Adverse Reactions
- nausea and vomiting
- diarrhea
- abdominal pain
- rash and pruritus
- increased liver enzymes
- tendinitis and tendon rupture
Drug Interactions
- increased risk of tendon rupture with corticosteroids
- decreased absorption with antacids and sucralfate
- increased risk of seizures with theophylline
- increased risk of QT prolongation with class IA and III antiarrhythmics
Curated Content: Needs Vetting Before Put to Clinical Use