← Search & browse all drugs
ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › QUINOLONE ANTIBACTERIALS › Other quinolones
rosoxacin
J01MB01
Adult Dosing
- Uncomplicated gonorrhea: 300 mg orally as a single dose, or 150 mg every 12 hours for 2 doses
Pediatric Dosing
- Safety and efficacy in pediatric patients have not been established (contraindicated in children due to risk of arthropathy)
Indications
- Treatment of uncomplicated gonorrhea caused by susceptible strains of Neisseria gonorrhoeae
Mechanism of Action
- Quinolone antibacterial agent; inhibits bacterial DNA synthesis by targeting DNA gyrase and topoisomerase IV
Contraindications
- Hypersensitivity to rosoxacin or other quinolone antibiotics
- Pregnancy and lactation
- Pediatric patients under 18 years of age due to potential for cartilage erosion
Adverse Reactions
- Nausea
- Vomiting
- Dizziness
- Headache
- Rash
- Photosensitivity
Drug Interactions
- Antacids containing magnesium or aluminum may decrease gastrointestinal absorption
- Theophylline levels may be increased, leading to toxicity
- Warfarin effects may be potentiated, increasing bleeding risk
Curated Content: Needs Vetting Before Put to Clinical Use