← Search & browse all drugs
ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › QUINOLONE ANTIBACTERIALS › Other quinolones
piromidic acid
J01MB03
Forms & Strengths
- Tablets: 300mg, 400mg
- Oral suspension: 100mg/5mL, 200mg/5mL
Adult Dosing
- Urinary tract infections: 400-600mg every 8-12 hours
- Prostatitis: 600mg every 8 hours
Pediatric Dosing
- 10-20mg/kg/day in 2-4 divided doses for children over 6 months
Indications
- Urinary tract infections
- Prostatitis
- Gonorrhea
Mechanism of Action
- Inhibits bacterial DNA gyrase and topoisomerase IV
- Interferes with bacterial DNA replication and transcription
Contraindications
- Hypersensitivity to piromidic acid or other quinolones
- Pregnancy and lactation
Adverse Reactions
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Allergic reactions
- Photosensitivity
- Central nervous system effects: dizziness, headache, insomnia
Drug Interactions
- Theophylline: increased theophylline levels
- Cimetidine: increased piromidic acid levels
- Warfarin: enhanced anticoagulant effect
- Antacids: decreased piromidic acid absorption
Curated Content: Needs Vetting Before Put to Clinical Use