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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › COMBINATIONS OF ANTIBACTERIALS › Combinations of antibacterials
norfloxacin and tinidazole
J01RA13
Forms & Strengths
- Norfloxacin 400mg and Tinidazole 600mg tablets
- Norfloxacin 400mg and Tinidazole 600mg oral suspension
Adult Dosing
- 1 tablet every 12 hours for 5-10 days for infections
- 1 tablet every 12 hours for 7-14 days for complicated infections
Pediatric Dosing
- Not recommended for patients under 18 years old
- Use with caution in patients with renal impairment
Indications
- Treatment of bacterial vaginosis
- Treatment of uncomplicated cervical and urethral gonorrhea
- Treatment of uncomplicated urinary tract infections
- Treatment of Helicobacter pylori infections in combination with other medications
Mechanism of Action
- Norfloxacin inhibits DNA gyrase and topoisomerase IV
- Tinidazole disrupts the helical structure of DNA and inhibits bacterial nucleic acid synthesis
Contraindications
- Hypersensitivity to norfloxacin, tinidazole, or other quinolones
- Pregnancy and lactation due to potential risk to the fetus and baby
- Patients with known or suspected CNS disorders
Adverse Reactions
- Nausea, vomiting, diarrhea, and abdominal pain
- Dizziness, headache, and fatigue
- Rash, pruritus, and urticaria
- Metallic taste and stomatitis
Drug Interactions
- Theophylline, caffeine, and warfarin may interact with norfloxacin
- Tinidazole may interact with ethanol, increasing the risk of disulfiram-like reaction
- Norfloxacin and tinidazole may interact with cyclosporine and decrease its levels
Curated Content: Needs Vetting Before Put to Clinical Use