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cefixime and ornidazole

J01RA15

Forms & Strengths

Tablets: 200mg cefixime and 100mg ornidazole
Tablets: 400mg cefixime and 200mg ornidazole
Capsules: 200mg cefixime and 100mg ornidazole
Suspension: 50mg/5mL cefixime and 25mg/5mL ornidazole

Adult Dosing

Typhoid fever: 200mg cefixime and 100mg ornidazole twice daily for 7-10 days
Uncomplicated UTI: 200mg cefixime and 100mg ornidazole twice daily for 5-7 days
Gonorrhea: 400mg cefixime and 200mg ornidazole single dose
GI infections: 200mg cefixime and 100mg ornidazole twice daily for 5-7 days

Pediatric Dosing

Above 6 months: 4-6mg/kg/day cefixime and 2-3mg/kg/day ornidazole in divided doses for 5-7 days
For children above 50kg, follow adult dosing
For children with typhoid fever: 6-8mg/kg/day cefixime and 3-4mg/kg/day ornidazole in divided doses for 7-10 days

Indications

Treatment of typhoid fever
Treatment of uncomplicated urinary tract infections
Treatment of gonorrhea
Treatment of gastrointestinal infections
Treatment of respiratory tract infections

Mechanism of Action

Cefixime is a third generation cephalosporin antibiotic with bactericidal action
Ornidazole is an antiprotozoal and antibacterial agent with action against anaerobic bacteria
Cefixime inhibits bacterial cell wall synthesis by binding to penicillin binding proteins
Ornidazole is metabolized to form reactive intermediates that interfere with DNA synthesis

Contraindications

Hypersensitivity to cefixime, other cephalosporins, or ornidazole
Pregnancy and lactation (use with caution)
Patients with a history of seizure disorders

Adverse Reactions

Diarrhea
Loose stools
Abdominal pain
Nausea and vomiting
Dizziness and headache
Allergic reactions such as rash and itching

Drug Interactions

Warfarin: increases anticoagulant effect
Aminoglycosides: increases nephrotoxicity risk
Chloramphenicol: increases risk of granulocytopenia
Theophylline: decreases theophylline clearance

Curated Content: Needs Vetting Before Put to Clinical Use