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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › OTHER ANTIBACTERIALS › Imidazole derivatives
ornidazole
J01XD03
Forms & Strengths
- Tablets: 500mg
- Capsules: 500mg
- Suspension: 200mg/5ml
Adult Dosing
- Trichomoniasis: 500mg-1g, PO, twice a day for 5-7 days
- Giardiasis: 1g, PO, twice a day for 3-5 days
- Amebiasis: 500mg-1g, PO, twice a day for 3-5 days
Pediatric Dosing
- Children > 3 years: 20-30mg/kg/day, PO, in 2 divided doses
- Children < 3 years: not recommended
- Alternative dosing for children: 500mg, PO, once a day for 3-5 days
Indications
- Trichomoniasis
- Giardiasis
- Amebiasis
- Anaerobic bacterial infections
- Amoebic dysentery
Mechanism of Action
- Interferes with DNA synthesis in microorganisms
- Forms reactive intermediates that damage DNA
- Inhibits microbial growth and proliferation
Contraindications
- Hypersensitivity to ornidazole or other imidazole derivatives
- Pregnancy (first trimester)
- Breastfeeding
- Concomitant use with disulfiram
Adverse Reactions
- Gastrointestinal disturbances (nausea, vomiting, diarrhea)
- Neurological effects (headache, dizziness, ataxia)
- Hepatotoxicity (rare)
- Allergic reactions (rash, pruritus)
Drug Interactions
- Disulfiram: increased risk of toxicity
- Phenytoin: decreased phenytoin levels
- Cyclosporine: decreased cyclosporine levels
- Warfarin: increased INR
Curated Content: Needs Vetting Before Put to Clinical Use