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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › OTHER ANTIBACTERIALS › Nitrofuran derivatives
nifurtoinol
J01XE02
Forms & Strengths
- Tablets: 100mg, 200mg
- Capsules: 100mg, 200mg
Adult Dosing
- Urinary tract infections: 100-200mg every 6 hours
- Bacterial cystitis: 200mg every 12 hours
- Chronic bacterial prostatitis: 100-200mg every 6 hours
Pediatric Dosing
- 1 month to 12 years: 5-7mg/kg/day divided every 6 hours
- >12 years: same as adult dosing
Indications
- Urinary tract infections
- Bacterial cystitis
- Chronic bacterial prostatitis
- Pyelonephritis
Mechanism of Action
- Inhibits bacterial DNA, RNA, and protein synthesis
- Interferes with bacterial cell wall formation
- Exerts bacteriostatic and bactericidal effects
Contraindications
- Hypersensitivity to nifurtoinol or other nitrofuran derivatives
- Pregnancy at term or during labor
- Infants <1 month due to risk of hemolysis
Adverse Reactions
- Nausea and vomiting
- Diarrhea and abdominal pain
- Allergic reactions (rash, itching, anaphylaxis)
- Hepatotoxicity and pulmonary toxicity (rare)
Drug Interactions
- Antacids: decrease nifurtoinol absorption
- Sulfonamides: increase risk of crystalluria
- Fluoroquinolones: increase risk of hepatotoxicity
Curated Content: Needs Vetting Before Put to Clinical Use