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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › OTHER ANTIBACTERIALS › Nitrofuran derivatives
nitrofurantoin, combinations
J01XE51
Forms & Strengths
- Tablets: 50mg, 100mg
- Capsules: 50mg, 100mg
- Oral suspension: 25mg/5mL
Adult Dosing
- 50-100mg every 6 hours
- Dose adjustment for renal impairment: CrCl <60mL/min, dose reduction recommended
Pediatric Dosing
- 5-7mg/kg/day divided into 4 doses, max 400mg/day
- >=12 years: same as adult dosing
Indications
- Urinary tract infections (UTIs) caused by susceptible strains
- Prophylaxis of recurrent UTIs
Mechanism of Action
- Inhibits bacterial DNA, RNA, and protein synthesis
- Active against Gram-positive and Gram-negative bacteria
Contraindications
- Anuria, oliguria, or significant renal impairment
- Hepatic impairment
- Pregnancy at term, near term, or during labor and delivery
Adverse Reactions
- Nausea, vomiting, diarrhea
- Hepatotoxicity, pulmonary reactions
- Peripheral neuropathy, hemolytic anemia
Drug Interactions
- Antacids, sulfinpyrazone: decreased absorption
- Probeneacid: increased renal clearance
- Uricosurics: decreased efficacy
Curated Content: Needs Vetting Before Put to Clinical Use