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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › OTHER ANTIBACTERIALS › Other antibacterials
fosfomycin
J01XX01
Forms & Strengths
- Granules for oral suspension 3g
- Tablets 3g
- Intravenous solution 1g/5ml, 2g/5ml
- Powder for injection 1g, 2g
Adult Dosing
- Uncomplicated urinary tract infections: 3g single dose
- Complicated urinary tract infections: 3g every 24-48 hours for 3-7 days
- Intravenous dose: 1-2g every 4-8 hours for 3-14 days
Pediatric Dosing
- Oral suspension: 30-40 mg/kg/dose every 8-12 hours for 5-7 days
- For children >12 years: same as adult dosing
Indications
- Uncomplicated urinary tract infections
- Complicated urinary tract infections
- Pneumonia
- Sepsis
- Prostatitis
Mechanism of Action
- Inhibits bacterial cell wall synthesis
- Inhibits MurA enzyme
- Prevents peptidoglycan synthesis
Contraindications
- Hypersensitivity to fosfomycin
- Severe renal impairment (CrCl <10ml/min)
Adverse Reactions
- Diarrhea
- Nausea
- Vomiting
- Abdominal pain
- Headache
- Dizziness
Drug Interactions
- Metoclopramide: decreases absorption
- Antacids: decreases absorption
- Warfarin: increases anticoagulant effect
- Cyclosporine: increases nephrotoxicity
Curated Content: Needs Vetting Before Put to Clinical Use