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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › OTHER ANTIBACTERIALS › Other antibacterials
tedizolid
J01XX11
Forms & Strengths
- Oral tablet: 200 mg
- Intravenous powder for injection: 200 mg
Adult Dosing
- Acute bacterial skin and skin structure infections (ABSSSI): 200 mg once daily orally or intravenously for 6 days
Pediatric Dosing
- Safety and efficacy in pediatric patients younger than 12 years have not been established
- Adolescents (12 to 17 years): 200 mg once daily orally or intravenously for 6 days
Indications
- Treatment of acute bacterial skin and skin structure infections (ABSSSI) caused by susceptible isolates of Gram-positive bacteria
Mechanism of Action
- Inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, preventing the formation of the 75S initiation complex
Contraindications
- Known hypersensitivity to tedizolid or other oxazolidinones
Adverse Reactions
- Nausea
- Headache
- Diarrhea
- Vomiting
- Dizziness
- Elevated transaminases
Drug Interactions
- Weak reversible monoamine oxidase inhibitor (MAOI); potential for interaction with adrenergic and serotonergic agents
- No clinically significant cytochrome P450 enzyme-mediated interactions identified
Curated Content: Needs Vetting Before Put to Clinical Use