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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIMYCOBACTERIALS › DRUGS FOR TREATMENT OF TUBERCULOSIS › Other drugs for treatment of tuberculosis
morinamide
J04AK04
Forms & Strengths
- Oral tablets: 200 mg
- Oral tablets: 400 mg
Adult Dosing
- Pulmonary tuberculosis: 1.5 g to 3 g daily, divided into 2 to 3 doses, used in combination with other antitubercular agents
Pediatric Dosing
- Safety and efficacy in pediatric patients not well established; use generally restricted to specialized pediatric tuberculosis regimens under expert guidance
Indications
- Treatment of pulmonary tuberculosis as a second-line antitubercular agent in multidrug combination regimens
Mechanism of Action
- Morpholine-containing derivative of nicotinamide; acts as a mycobacterial replication inhibitor with bactericidal activity against Mycobacterium tuberculosis
Contraindications
- Hypersensitivity to morinamide or related nicotinamide derivatives
- Severe hepatic impairment
- Active acute liver disease
Adverse Reactions
- Hepatotoxicity (elevated transaminases, jaundice)
- Gastrointestinal distress (nausea, vomiting, anorexia)
- Hyperuricemia and arthralgia
- Flushing and headache
Drug Interactions
- Other hepatotoxic drugs (increased risk of severe liver injury)
- Antihypertensive agents (potential additive hypotensive effects)
- Alcohol (increased risk of hepatotoxicity)
Curated Content: Needs Vetting Before Put to Clinical Use