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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIVIRALS FOR SYSTEMIC USE › DIRECT ACTING ANTIVIRALS › Protease inhibitors
indinavir
J05AE02
Forms & Strengths
- Capsules: 100mg, 200mg, 333mg, 400mg
Adult Dosing
- 800mg q8h, 1000mg q8h with ritonavir boosting
Pediatric Dosing
- Not recommended for children under 4 years, dose based on body surface area for children over 4 years
Indications
- HIV-1 infection in combination with other antiretroviral agents
Mechanism of Action
- Inhibits HIV-1 protease, preventing viral replication
Contraindications
- Hypersensitivity, severe hepatic impairment, co-administration with certain medications
Adverse Reactions
- Nephrolithiasis, hyperbilirubinemia, lipodystrophy, GI disturbances
Drug Interactions
- Contraindicated with astemizole, terfenadine, and certain statins; caution with rifampicin, St. John's Wort
Curated Content: Needs Vetting Before Put to Clinical Use