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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIVIRALS FOR SYSTEMIC USE › DIRECT ACTING ANTIVIRALS › Protease inhibitors
ritonavir
J05AE03
Forms & Strengths
- Tablets: 100mg
- Soft gelatin capsules: 100mg
- Oral solution: 80mg/ml
- Film-coated tablets: 100mg
Adult Dosing
- Antiviral boostering: 100-200mg/day
- HIV treatment: 600mg twice daily
- Hepatitis C treatment: dose varies by regimen
Pediatric Dosing
- HIV treatment: 350-450mg/m2 twice daily
- Dose adjustment for children < 1 year may be needed
- Oral solution recommended for pediatric use
Indications
- HIV-1 infection treatment
- Hepatitis C treatment as part of combination therapy
- Off-label for other viral infections
Mechanism of Action
- Protease inhibitor, prevents viral replication
- Inhibits HIV protease enzyme
- Increases levels of other protease inhibitors
Contraindications
- Hypersensitivity to ritonavir
- Coadministration with certain medications (e.g. alfuzosin, amiodarone)
- Pregnancy and lactation (use with caution)
Adverse Reactions
- Gastrointestinal disturbances (nausea, diarrhea)
- Metabolic disorders (hyperlipidemia, insulin resistance)
- Increased risk of bleeding
Drug Interactions
- CYP3A4 substrates (e.g. statins, benzodiazepines)
- Anticoagulants (e.g. warfarin)
- St. John's Wort (decreases ritonavir levels)
Curated Content: Needs Vetting Before Put to Clinical Use