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ANTIINFECTIVES FOR SYSTEMIC USE › ANTIVIRALS FOR SYSTEMIC USE › DIRECT ACTING ANTIVIRALS › Other antivirals
fostemsavir
J05AX29
Adult Dosing
- 600mg orally every 8 hours for treatment-experienced patients
- 1200mg oral loading dose, then 600mg every 8 hours for HIV-1 infection
Pediatric Dosing
- Safety and efficacy not established in pediatric patients
- Use not recommended in patients under 18 years
Indications
- Treatment of HIV-1 infection in heavily treatment-experienced adults
- In combination with other antiretroviral agents for HIV-1 infection
Mechanism of Action
- HIV-1 gp120 attachment inhibitor
- Blocks HIV-1 attachment to the host cell CD4 receptors
- Inhibits viral replication
Contraindications
- None established
- Use caution in patients with severe renal impairment or at risk of renal impairment
Adverse Reactions
- Nausea
- Diarrhea
- Headache
- Dizziness
- Rash
- Abdominal pain
Drug Interactions
- May interact with OCT2 and MATE1 substrates
- Monitor for increased concentrations of OCT2 and MATE1 substrates
- Avoid concomitant use with certain antiretroviral agents
Curated Content: Needs Vetting Before Put to Clinical Use