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ANTIINFECTIVES FOR SYSTEMIC USE › VACCINES › BACTERIAL VACCINES › Tuberculosis vaccines
tuberculosis, live attenuated
J07AN01
Forms & Strengths
- lyophilized powder for injection
- freeze-dried powder for oral administration
Adult Dosing
- 0.5 mL IM, 1 dose
- 0.1 mL ID, 1 dose
Pediatric Dosing
- 0.1 mL ID, 1 dose, from birth to 12 months
- 0.5 mL IM, 1 dose, 1-12 years
Indications
- prevention of tuberculosis in individuals exposed to tuberculosis
- tuberculosis prophylaxis
Mechanism of Action
- induces cell-mediated immunity to Mycobacterium tuberculosis
- stimulates production of cytokines and activation of macrophages
Contraindications
- HIV infection
- immunosuppression
- pregnancy
- fever or active TB disease
Adverse Reactions
- local reaction at injection site
- fever
- headache
- fatigue
- axillary lymphadenitis
Drug Interactions
- immunosuppressants
- corticosteroids
- live vaccines
- BCG vaccine and other live vaccines should not be administered simultaneously
Curated Content: Needs Vetting Before Put to Clinical Use