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ANTIINFECTIVES FOR SYSTEMIC USE › VACCINES › VIRAL VACCINES › Hepatitis vaccines
hepatitis B, purified antigen
J07BC01
Forms & Strengths
- Intramuscular injection: 10-20 mcg
- Paediatric formulation: 5-10 mcg
- Combination vaccines available
Adult Dosing
- Primary immunization: 1 mL (20 mcg) at 0, 1, 6 months
- Accelerated schedule: 1 mL (20 mcg) at 0, 7, 21 days, 6 months
- Booster dose: 1 mL (20 mcg) at 12 months
Pediatric Dosing
- Infants: 0.5 mL (5 mcg) at birth, 1, 6 months
- Children 1-15 years: 0.5 mL (10 mcg) at 0, 1, 6 months
Indications
- Prevention of hepatitis B virus (HBV) infection
- Pre-exposure prophylaxis in health workers, travellers
- Post-exposure prophylaxis in high-risk groups
Mechanism of Action
- Stimulates active immunity against HBV surface antigen
- Induces production of anti-HBs antibodies
Contraindications
- Hypersensitivity to hepatitis B vaccine or components
- Severe febrile illness
- Known history of sensitivity to yeast
Adverse Reactions
- Injection-site reactions (pain, redness, swelling)
- Fatigue, fever, headache
- Allergic reactions (rare)
Drug Interactions
- Concomitant use with immunosuppressants: decreased efficacy
- Co-administration with other vaccines: potential interference
Curated Content: Needs Vetting Before Put to Clinical Use