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ANTIINFECTIVES FOR SYSTEMIC USE › VACCINES › VIRAL VACCINES › Poliomyelitis vaccines
poliomyelitis oral, trivalent, live attenuated
J07BF02
Forms & Strengths
- Trivalent oral suspension
- Trivalent oral drops
Adult Dosing
- 2 doses 4-8 weeks apart for primary series
- 1 booster dose at 4-6 years or at least 4-8 weeks after primary series
Pediatric Dosing
- 2 doses 4-8 weeks apart for primary series, starting at 6-8 weeks
- 1 booster dose at 12-18 months, with final booster at 4-6 years
Indications
- Prevention of poliomyelitis
- Mass vaccination campaigns in outbreak response
Mechanism of Action
- Induces mucosal immunity
- Stimulates production of neutralizing antibodies
Contraindications
- Immunodeficiency
- Severe combined immunodeficiency
- Pregnancy in women with certain high-risk conditions
Adverse Reactions
- Mild gastrointestinal symptoms
- Allergic reactions
- Vaccine-associated paralytic poliomyelitis (rare)
Drug Interactions
- Concomitant administration with other live vaccines
- Immune globulins may interfere with vaccine efficacy
Curated Content: Needs Vetting Before Put to Clinical Use