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ANTIINFECTIVES FOR SYSTEMIC USE › VACCINES › VIRAL VACCINES › Rota virus diarrhea vaccines
rota virus, live attenuated
J07BH01
Forms & Strengths
- Oral liquid formulation
- Contains live attenuated human rotavirus strains
Adult Dosing
- Not indicated for adults
- Vaccine is administered to infants
Pediatric Dosing
- First dose at 2 months of age
- Second dose at 4 months of age
- Third dose at 6 months of age
- Series completion by 8 months of age
Indications
- Prevention of rotavirus gastroenteritis in infants
- Reduction of hospitalization rates due to rotavirus infection
Mechanism of Action
- Stimulates immune response to protect against rotavirus infection
- Induces production of neutralizing antibodies
Contraindications
- Hypersensitivity to components of the vaccine
- History of severe allergic reaction to previous rotavirus vaccine
- Severe combined immunodeficiency
- Congenital immunodeficiency
Adverse Reactions
- Fever
- Vomiting
- Diarrhea
- Abdominal pain
- Intussusception (rare)
Drug Interactions
- Inactivated vaccines can be co-administered
- Live vaccines should not be administered within 8 weeks
- Immunosuppressive agents may decrease vaccine efficacy
Curated Content: Needs Vetting Before Put to Clinical Use