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ANTIINFECTIVES FOR SYSTEMIC USE › VACCINES › VIRAL VACCINES › Other viral vaccines
smallpox and mpox vaccines
J07BX01
Forms & Strengths
- Lyophilized powder for reconstitution
- Single-dose vials
- Multidose vials
Adult Dosing
- Primary series: 2 doses, 4 weeks apart
- Boosters: 1 dose every 10 years
- Immunocompromised: consult CDC guidelines
Pediatric Dosing
- Not recommended for children under 1 year
- Primary series: 2 doses, 4 weeks apart, for children 1-12 years
- Adolescents 13-18 years: follow adult dosing
Indications
- Active immunization against smallpox (variola) and mpox (monkeypox)
- Pre-exposure prophylaxis for individuals at high risk
- Post-exposure prophylaxis for close contacts
Mechanism of Action
- Induces humoral and cell-mediated immune responses
- Stimulates production of antibodies against viral antigens
- Provides protective immunity against smallpox and mpox viruses
Contraindications
- Severe allergic reaction to vaccine components or previous dose
- Immunodeficiency or immunosuppression (caution advised)
- Pregnancy or breastfeeding (consult CDC guidelines)
Adverse Reactions
- Mild: injection-site pain, redness, swelling, fatigue, headache
- Moderate: fever, lymphadenopathy, myalgia
- Severe: anaphylaxis, encephalitis, myocarditis (rare)
Drug Interactions
- Immunosuppressive agents: may decrease vaccine efficacy
- Other live vaccines: administer at least 4 weeks apart
- Antiviral medications: no known interactions
Curated Content: Needs Vetting Before Put to Clinical Use